2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-

2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-

0990CL

CAS: 511514-03-7

Molecular Formula: C21H21N5

2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl- - Names and Identifiers

Name	0990CL
Synonyms	185582 0990CL 4-phenyl-N-(4,4,6-trimethyl-1H-pyrimidin-2-yl)quinazolin-2-amine 2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl- (4-phenyl-quinazolin-2-yl)-(4,6,6-trimethyl-1,6-dihydro-pyrimidin-2-yl)-amine
CAS	511514-03-7

2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl- - Physico-chemical Properties

Molecular Formula	C21H21N5
Molar Mass	343.42494
Density	1.21±0.1 g/cm3(Predicted)
Boling Point	519.5±58.0 °C(Predicted)
pKa	7.10±0.60(Predicted)
Storage Condition	2-8°C，密封，干燥
In vitro study	0990CL(100 nM-1 μM; 24 hours) is able to restore α2AR/Gαimediated cAMP levels elicited by Fsk and UK14304 in HEK293 GloSensor cells. When the dosage is at 100 nM, it restores 31% of the reduction of cAMP.0990CL(30 μM; pre-treatment 30mins) shows selectivity for Gαi1 over Gαq. It demonstrates selectivity for Gαiand Gαq and results in a maximum endpoint fluorescence reduction of 38±8% and 10%, respectively.

2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl- - Reference Information

biological activity	099ocl is a heterotrimeric gαi subunit specific inhibitor capable of directly interacting with gαi. 0990CL can block the regulation of cAMP mediated by Alpha 2AR.
Target	IC50: G αi subunit

Last Update：2024-04-09 21:11:58

2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-

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2-Quinazolinamine, N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-

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